Mixing Weed and Antidepressants: Understanding the Risks

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Weed and antidepressant pills and tablets

The use of cannabis, commonly referred to as weed, has been on the rise, particularly in places where its recreational or medicinal use is legal. Meanwhile, antidepressants are among the most commonly prescribed medications globally, used to treat a range of mental health conditions like depression and anxiety. Given the prevalence of both substances, it’s crucial to understand the implications of their concurrent use.

This article explores the potential risks and considerations when mixing weed with various types of antidepressants.

The Nature of Antidepressants

Antidepressants are a diverse group of medications designed to alter brain chemistry to alleviate symptoms of mental health disorders. The main types include Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAOIs), and a typical antidepressants. These drugs target different neurotransmitters like serotonin, norepinephrine, and dopamine, each playing vital roles in mood regulation, executive functioning, and bodily processes.

Cannabis and Its Effects

Cannabis, or marijuana, is known for its psychoactive properties primarily due to compounds like THC and CBD. It can induce relaxation, euphoria, and altered sensory perceptions. However, heavy and long-term use can impair cognitive functions like attention and memory.

Interactions Between Weed and Antidepressants


With SSRIs and SNRIs, the interaction with cannabis can be complex. Cannabis may interfere with the way these medications are metabolized, leading to higher levels in the bloodstream. This can increase the risk of side effects like serotonin syndrome, a potentially life-threatening condition. SNRIs, metabolized differently, also face a similar risk when combined with cannabis.

TCAs and MAOIs

The combination of cannabis with older antidepressants like TCAs and MAOIs is particularly concerning. Cannabis can significantly affect the levels of these drugs in the body, potentially leading to severe side effects like tachycardia, confusion, mood swings, and even life-threatening interactions.

Potential Risks and Side Effects

The potential risks of mixing weed with antidepressants vary based on the type of medication and the individual’s health condition. These can range from mild side effects to severe health complications, including increased anxiety, cognitive impairment, and heart problems. It’s important to note that the specific effects can vary greatly from person to person.

Clinical Perspectives

Medical professionals often advise against the concurrent use of cannabis and antidepressants, especially in patients with severe mental health conditions. Allan Schwartz, LCSW, PhD, notes that abstaining from cannabis can lead to significant improvements in mood and functioning for patients on antidepressants. There’s also a concern that patients using both may have lower adherence to treatment protocols.


Mixing weed with antidepressants can be risky and may lead to various adverse effects. The interactions depend on the type of antidepressant and the individual’s health. It’s essential for patients to discuss their cannabis use with their healthcare provider to ensure safe and effective treatment. As with any medication, it’s crucial to adhere to medical advice and not self-medicate or mix drugs without professional guidance.