Cyclobenzaprine (Flexeril): Addiction, Abuse and Side Effects

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Realistic depiction of Cyclobenzaprine tablets with a focus on potential abuse and addiction risks.

Cyclobenzaprine, commonly known by its brand name Flexeril, is a muscle relaxant prescribed for the treatment of pain and discomfort related to muscle injuries. Its primary use is as a short-term remedy for muscle spasms arising from strains, sprains, and spasms. While it is generally considered non-addictive, there’s growing evidence suggesting its potential for misuse and addiction.

Cyclobenzaprine: The Basics

Cyclobenzaprine falls under the category of central nervous system acting muscle relaxants. It’s chemically akin to tricyclic antidepressants and acts on the central nervous system to block pain sensations from spasming muscles to the brain. This blocking mechanism is what may contribute to its abuse.

It is typical prescription involves short-term usage, complementing physical therapy and rest to treat muscle injuries and certain musculoskeletal disorders like fibromyalgia.

The Risks of Cyclobenzaprine Abuse

Despite not being classified as a controlled substance in the United States, it has abuse and addiction potential. It depresses the central nervous system, which can be desirable for some, leading to misuse. High doses can alter brain neurotransmitters’ activity, leading to physical dependence and addiction. The risk of abuse rises when Cyclobenzaprine is used in combination with substances like alcohol or benzodiazepines, as they can amplify each other’s effects, resulting in intensified sedation or high.

Side Effects of Abuse

Abuse of Cyclobenzaprine may lead to various side effects, including:

  • Drowsiness
  • Dry mouth
  • Fatigue
  • Headaches
  • Dizziness
  • Nausea
  • Constipation
  • Blurred vision
  • Confusion
  • Acid reflux
  • Abdominal pain
  • Fever
  • Nervousness
  • Urination problems

In severe cases, an overdose of this drug can cause health problems like cardiac arrest, low blood pressure, seizures, and potentially death.

Recognizing Cyclobenzaprine Addiction

Addiction manifests in several ways:

  • Continued use beyond the prescribed period or necessity.
  • Increased tolerance, requiring more of the drug for the same effects.
  • Preoccupation with obtaining and using the drug.
  • Inability to stop using.
  • Withdrawal symptoms upon cessation.

Treatment and Recovery

Recovery from Cyclobenzaprine addiction often necessitates a comprehensive approach, including detoxification, therapy, and ongoing support. Detox programs can help manage withdrawal symptoms, which can range from mild (like fatigue and headache) to more severe (such as fever and anxiety).


While Cyclobenzaprine is effective for short-term treatment of muscle spasms, its potential for abuse and addiction should not be overlooked. Awareness of the signs of addiction and timely intervention are key to preventing and addressing misuse of this medication.